Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion
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چکیده
منابع مشابه
Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion.
We read with great interest the article ‘Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis’ by Chunqing Guo et al. In this paper, the authors used anti-Gr1 antibody to deplete myeloid-derived suppressor cells (MDSCs) in arthritic mice and they found that it reduced disease severity and Th17 response. However, they did not report the efficie...
متن کاملResponse to: 'Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion' by Xing et al.
Myeloid-derived suppressor cell (MDSC) is a heterogeneous myeloid cell population that can broadly be characterised as CD11bGr-1 cells in mice. MDSC can be further classified into two main cell subsets, granulocytic MDSC (G-MDSC, CD11bLy6CLy6G) and monocytic MDSC (M-MDSC, CD11bLy6CLy6G). To address the role of MDSC in disease settings (eg, cancer and autoimmune disorders) and to evaluate the po...
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Immunosuppressive CD11b(+)Gr1(+) myeloid-derived suppressor cells and TGF-β have been shown to negatively regulate host immunity against allografts. Our results demonstrated that Smad3-deficient mice or mice reconstituted with Smad3-deficient hematopoietic cells rejected allogeneic skin or heart grafts in a significantly slower manner compared with littermates or wild-type (WT) control mice. Tr...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2016
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2016-209786